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Downstream Processing Engineer

Company: Inscripta Inc
Location: Pleasanton
Posted on: May 28, 2023

Job Description:

Inscripta - is a life science technology company committed to creating a cleaner, healthier, and more sustainable world through biomanufacturing. A global leader in genome engineering, our innovations are designed to unlock the full potential of the bioeconomy. We are committed to the continued development of critical technologies that enable scientists to bolster and expand domestic biomanufacturing, and spur new, safe, and secure biotech innovations. Inscripta supports partners around the world from facilities in Pleasanton and Burlingame, California.

Inscripta has an opening for a Downstream Processing Engineer located in Pleasanton, California


We are seeking a Downstream Processing Engineer to lead/assist in identification, development, and scaling of multiple purification processes of small molecule products from fermentation broths. The successful candidate will bring previous expertise in the development and scaling of downstream processing methods, a fundamental understanding of upstream and fermentation processes, and will also have the intellectual flexibility to draw on best practices from related disciplines including the chemical, pharmaceutical and petrochemical industries.

This role is a hands-on, individual contributor position. Responsibilities include design and execution of experiments in our internal laboratory as well as coordinating and supporting work at external CRO/CMOs. This hands-on position will also contribute to expanding our internal DSP Process Research laboratory capabilities.


--- Design and execute experiments to develop commercially viable processes for the recovery and purification of microbial fermentation-based products to meet project milestones including product yield, purity, and performance at industrial scale.

--- Analyze, summarize, interpret, and present experimental results to others in a collaborative team environment.

--- Collaborate with our analytical team to establish new analytical approaches and develop and implement sampling and sample processing schemes for evaluating process streams.

--- Establish and expand DSP laboratory capabilities as needed, including selecting, acquiring, and setting up equipment.

--- Collaborate with cross-functional teams to ensure seamless technology transfer from development to manufacturing.

--- Lead/assist generation of technology transfer package, support technology transfer, scale up activities, and pilot campaigns.

--- Interact with and monitor outside collaborators to assist in process scale-up and commercialization.



--- B.S. / M.S. / Ph.D. in Chemistry / Chemical Engineering or a related discipline with at least two years of industrial experience working directly with small molecule products at bench and pilot-scale bioprocess development.

--- Experience with a range of commercially-applicable unit operations such as cell isolation, cell disruption, extraction, liquid-liquid and liquid-solid separations, distillation, drying, filtration, crystallization, chromatography, etc.

--- Expertise in experimental design and meticulous execution - strong data analysis and statistical skills including design of experiments (DOE) experience.

--- Fundamental knowledge of biochemical & process engineering principles including mass balance & transport, fluid dynamics, and process control.

--- Strong time management skills, able to multitask effectively, and to adapt work plans as needed while ensuring maximum efficiency.

--- Strong organizational skills and attention to detail.

--- Outstanding team player with strong interpersonal and communication skills.

Preferred Qualifications:

--- Experience with process and cost modeling, Aspen/CHEMCAD simulation.

--- Strong background in organic chemistry.

Inscripta offers a competitive base salary, bonus plan, benefits package, 401k match and an attractive equity program to all team members. Starting Salary Range: $95,000 - $150,000 per year. This salary range is provided per current averages and expectations. The salary and job title for this opening will be based on the selected candidate's qualifications and experience and may be outside this range. Join us and work with a cutting edge organization creating cutting edge technology. At Inscripta we don't just accept difference - we celebrate it, support it, and thrive on it for the benefit of our employees, our innovation, and our community. We are proud to be an equal opportunity workplace because the more inclusive we are as a company, the better our work will be. Inscripta is headquartered in Pleasanton, CA.

Keywords: Inscripta Inc, Pleasanton , Downstream Processing Engineer, Engineering , Pleasanton, California

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