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Senior Scientist, Bioinformatics

Company: Hoffmann-La Roche Ltd
Location: Pleasanton
Posted on: May 3, 2021

Job Description:

We are seeking a talented and motivated Bioinformatics Senior Scientist, who will be an integral member of the Research team contributing to the research and development of qPCR tests for cobas x800, cobas Liat, and digital PCR. The individual brings subject matter expertise to work closely within the Bioinformatics team, wet lab scientists in R&D as well as internal & external customers.


  • Hand-on work on mining for biomarker discovery for medical conditions of interest

  • Develop and maintain Agile Assay Design (AAD) bioinformatics tools for qPCR tests

  • NGS data analysis tools and/or workflows and their for R&D projects

  • Deploy these tools on Roche intranet (Galaxy) and train scientists to use themResponsibilities

  • Hands-on biomarker discovery data mining for medical conditions of interest based on available microarray and NGS data.

  • Develop & support Agile Assay Design (AAD) bioinformatics tools for multiplexed qPCR assays on the Roche cobas x800, Liat Systems and digital PCR.

  • Design and model wet lab data to integrated into informatics tools

  • Understand what tools are needed, based on interactions with wet lab Scientists and experimental data

  • Design wet lab experiments to generate data and develop model based on these data

  • Recommend approaches for NGS Data analyses, develop new and improved existing informatics tools and workflows for NGS data analyses for internal R&D projects

  • Implement, and deliver new or creative approaches in the scope of the function for scientific research,:.

  • Training scientists to use AAD and NGS tools on Roche intranet and other cloud platforms.

  • Presents findings and project status reviews at internal seminars and meetings. Applies technical writing skills to produce reports and documents. Prepares summaries, internal reports presentations, manuscripts, etc.

  • Establish and maintain productive relationships with Roche IT.


  • Bachelor's degree and in Biological/Life Sciences, Chemistry, Biochemistry, Informatics or related field, or equivalent combination of education and work experience, typically 5 years of relevant experience, or Master's degree with 2+ years' experience or a Ph.D.

  • Educational background and relevant work experience in Bioinformatics, Computational Biology, Computer Science or Molecular Biology preferred. Experience in assay optimization, experimental design, versatile laboratory practice, data analysis, and modelling.

  • Proficient in using scripting programming languages: Python, R, Perl in a distributed Linux environment.

  • Strong data modelling skills.

  • Have a good understanding of molecular biology, including PCR, NGS. Prior experience in molecular biology wet lab work is a plus, as well as prior experience in the biology of infectious diseases.

  • Prior work supporting scientific informatics data mining, big data, machine learning is a plus.

  • Understanding of academic bioinformatics tools used for NGS data analyses and PCR.

  • Ability to independently implement and support informatics solutions that meet user's needs.

  • Statistics, C++ or Java proficiency as well as understanding or prior experience with relational databases is a plus.

  • Prior experience using cloud computing, computer clusters and Galaxy is a plus

  • Prior experience developing diagnostics tests is a plus, but not required.

  • Good written & verbal communication and scientific presentation skills.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

If you have a disability and need an accommodation in connection with the on-line application process, please email us at

Keywords: Hoffmann-La Roche Ltd, Pleasanton , Senior Scientist, Bioinformatics, Other , Pleasanton, California

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