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Principal Scientist I (PHC)

Company: Hoffmann-La Roche Ltd
Location: Pleasanton
Posted on: May 3, 2021

Job Description:

We are looking for an outstanding Principal Scientist in the area of human diagnostic development and digital PCR. The main responsibilities will include research and development in the areas of novel reagents and protocols for automated nucleic acid quantification, digital PCR, other molecular diagnostics assay technologies, various analytical processes and methods as well as participation in cross-functional projects across the entire R&D organization.

An advanced degree in Biology, Chemistry, Biochemistry, Chemical Biology, or related fields, and relevant industry or post-doctoral experience is highly preferred. The position requires a minimum of 8 years of research and development experience with a track record of innovation and peer reviewed publications, and it is preferred that the candidates have supervisory management experience in leading small research teams.

The Principal Scientist will provide general expertise in nucleic acid purification and amplification techniques, and participate in development and evaluation of new technologies and products. Hands-on experimental skills and demonstrated ability to translate innovation into products or proof of concept are required. The successful candidate will have leadership responsibility in a development team and represent development efforts in a cross-functional team. Experience in nucleic acid extraction and amplification technologies, digital PCR methods and analysis, and diagnostics is highly desirable.

Key Roles & Responsibilities

  • Aligns project and team goals with the company's business vision.

  • Develops product concepts aligned with customer requirements and product specifications, and translates them into focused scientific activities.

  • Plans, designs, and executes advanced independent or multi-disciplinary research/development experiments driven by strategic business needs.

  • Manages projects and teams, provides scientific/technical direction, and designates accountability for product research and development activities. Gives people assignments and training to develop their abilities.

  • Serves as a subject matter expert at various management levels. Prepares timelines and assessments of project progress and critical factors, and establishes priorities. Assumes responsibility for timely completion of projects, and resolves technical issues.

  • Ensures activities meet performance/quality expectations and are consistent with project critical path.

  • Ensures technical activities under delegated supervision are conducted within of internal and external guidelines and regulations.

  • Interacts with other departments to further project goals. Responsible for the transfer of prototype product technology and documentation from Research to Development and/or to Manufacturing. Provides information and assistance to other departments to support product scale-up, manufacture, launch and sales.

  • Recommends new approaches, expansion or curtailment of project technical activities based on experimental results or new scientific information. Adjusts direction of research activities accordingly as scientific findings warrant.

  • Communicates progress of efforts to Director and other departments to assure awareness of current status of projects. Provides top line review of experimental results, and secondary review of experimental data. Prepares comprehensive written and verbal project status reports, and written manuscripts for publication in some cases. Presents findings or comprehensive project status reviews at internal & external meetings. Applies advanced technical writing skills to produce reports and documents.

  • Influences senior management decisions that have an impact on business direction of the area. Makes decisions under consultative direction that have an impact on business direction of the area. Decisions have a long term effect on the objectives of the function and/or area.


  • Bachelor's Degree in Biological/Life Sciences, Chemistry, Biochemistry or related field. Plus 7 years relevant industry experience.

  • Prefer Ph.D. with 8 -10 years relevant industry experience

  • Experience in assay optimization, experimental design, versatile laboratory practice, data analysis, and data and concept presentation.

Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

If you have a disability and need an accommodation in connection with the on-line application process, please email us at

Keywords: Hoffmann-La Roche Ltd, Pleasanton , Principal Scientist I (PHC), Other , Pleasanton, California

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