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Principal Scientist I

Company: F. Hoffmann-La Roche Gruppe
Location: Pleasanton
Posted on: May 3, 2021

Job Description:

  • Leads, manages and mentors a team of Scientists and Sr. Scientists in the design, planning and execution of assigned research. Performs hand-on research activities at the bench.
  • Generates technical requirements for new instruments and next generation sequencing platform. Validates workflows and applications for new next generation sequencing platform.
  • Independently defines and plans project goals, and achieves them with the help of the team. Makes recommendations, and when appropriate, acts independently to resolve scientific problems encountered during experimental procedures. Ensures activities are consistent with project critical path, and responds appropriately to changing priorities.
  • Accurately, consistently, and promptly records experimental methods, materials and results in electronic laboratory notebooks. Analyzes data, evaluates results, forms conclusions and implements/documents process improvements.
  • Integrates previous and current results to determine next experimental steps and the impact on long-term project goals.
  • Guides team members to the planning, prioritization, execution and analysis of experiments, and helps them analyze and interpret results, generate reports, troubleshoot problems and formulate solutions based on scientific knowledge and past experience.
  • Presents findings at group or departmental meetings. Applies advanced technical writing skills to produce reports
  • and documents. Prepares summaries, memos, internal reports, presentations, manuscripts, etc.
  • Serves as a resource to other departments (e.g., Development, Manufacturing/Operations, Quality, Marketing, Regulatory Affairs, Clinical Studies, Bioinformatics and International Technical Services), provides timely response and follow-ups. Participates in the expeditious transfer of products and technologies by providing scientific knowledge and assistance.
  • Has supervisory responsibilities; provides guidance to new team members and builds professional relationships.
  • Work involves troubleshooting and resolving difficult problems in creative ways. Takes a new perspective on existing solutions, exploring and implementing new concepts and methodologies.


To perform this job successfully, an individual must be able to perform each responsibility satisfactorily. The requirements listed below are representative of the knowledge, skills, and/or abilities required. Reasonable accommodations may be made to enable individuals with disabilities to perform the responsibilities.

  • Formal Training/Education: MS required in Biology, Chemistry, Biological Science or equivalent. PhD preferred.
  • Typically 3 years of relevant experience, 6+ years preferred
  • Experience in team management and mentoring.
  • Knowledge and experience in experimental design, data analysis, and data and concept presentation.
  • Strong communication and organization skills.
  • General molecular biology hands-on skills.
  • Experience in nucleic acid sample preparation, including DNA / RNA extractions, QC, library construction, target enrichment.
  • Experience with new instrument and platform development.
  • Experience with various types of clinical specimen and sample types for NGS, including purified DNA, bacterial pellets, fresh and FFPE tissue material, blood, etc.
  • Experience in verification / validation experimental design, statistical data analysis and interpretation.
  • Travel Requirements: 5% Based on business needs
Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individuals race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.

If you have a disability and need an accommodation in connection with the on-line application process, please email us at .

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Keywords: F. Hoffmann-La Roche Gruppe, Pleasanton , Principal Scientist I, Other , Pleasanton, California

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