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Staff Scientist, Applications Development (Molecular Diagnostics)

Company: Bio-Rad Laboratories
Location: Pleasanton
Posted on: June 9, 2021

Job Description:

At the Clinical Diagnostics Group (a division of Bio-Rad), we are undergoing a rapid evolution, which includes building an R&D team focused on molecular diagnostics, leveraging droplet digital PCR (ddPCR), which uses microfluidic chips to generate nanoliter-sized droplets as reaction vessels to power this extremely precise digital nucleic acid measurement method. Bio-Rad has established the market lead in digital PCR and now we're expanding into molecular diagnostics for our clinical laboratory customers. We believe our partition technology (creating hundreds of thousands of droplets) will open up new avenues in the clinical diagnostics markets. To support this evolution, we are looking for a talented Applications Lead to be a member of the R&D Mol Dx leadership team for the Clinical Diagnostics Group's efforts to expand into Reproductive Health, Infectious Diseases and Human Genetics.

What We Are Looking For:

An exceptional candidate passionate about improving healthcare, with a significant track record of developing novel assays and who is highly motivated in applying ddPCR technology to clinical problems. The successful candidate will thrive in a matrixed environment and will demonstrate technical acumen coupled with experience interacting with experts in the Reproductive Health field (NIPT, Carrier Screening, Pre-eclampsia, Endometriosis).


  • Lead the creation of content and data, with support from commercial and scientific affair team partners, for application notes, scientific posters and journal publications to advance partnerships with key opinion leaders in the human genetics/reproductive health fields.
  • Establish close partnerships with Marketing, Scientific Affairs and Business Development teams to drive timely and effective collaborations with external clinical and academic partners.
  • Design, perform and troubleshoot experiments with the goal of developing novel molecular assays on digital PCR for external partners.
  • Design and execute experiments, perform data analysis and effectively communicate results to technical and non-technical audiences.
  • Write documentation (plans, protocols, reports, manuscripts) and make presentations as needed.
  • Provide technical support for transfer of assays and applications to external partners for their analytical and clinical validation.
  • Present on specific product applications and scientific findings at conferences, seminars/webinars, and tradeshows.
  • Serve as consultant and support the Assay Development team on experimental design, assay design and data analysis that meet project objectives as needed.
  • Manage alpha and beta testing, early access activities for new products in development.
  • Mentor and engage more junior scientists and team members to create high-performing Molecular Diagnostics team.
  • Participate in regular data and design reviews.
  • Identify and develop new technology suitable for intellectual property expansion and work with legal teams to file patents.
  • Support the development of the physical product specifications and configurations that deliver the ideal product performance.
  • Must be willing to travel up to 25% of the time (once travel is allowed and safe again).
  • Successfully interact and align with various functional roles as needed (including Marketing, Project Managers, Software Engineers, Computational Biologists, Biostatisticians, QA, RA, and Manufacturing) within the Digital Biology and Clinical Diagnostics Groups to drive projects to completion.


  • PhD in Molecular Biology, Genetics or related field with 8+ years of industry experience (or MS with 10+ years of experience) highlighted with successful collaborations with experts in the field
  • Track record of self-motivated design, execution and analysis of experiments on aggressive schedules in a rapidly changing environment.
  • Experience with nucleic acid technology relating to PCR, qPCR, and digital PCR with special emphasis on developing highly multiplexed PCR assays. This position requires wet lab testing.
  • Highly knowledgeable in nucleic acid sample preparation and characterization is essential. Prior experience working with cell-free DNA and/or creating nucleic acid calibrators and controls a plus.
  • Detailed working knowledge of modern sequencing methods, the field of reproductive health and human genomics, and informatics. Demonstrated understanding of all "wet lab" elements in and around NGS, including sample and target preparation, amplification and sequencing biochemistries.
  • Clinical/diagnostic laboratory experience desirable.
  • Experience in laboratory-developed tests is a plus.
  • Excellent verbal and written communication skills, logical and analytical thinking, ability to multitask, work independently and on a team, and the ability to learn, troubleshoot, and problem solve are essential.
  • Track record of peer-reviewed publications in high-impact journals, intellectual property filings, presentations at conferences is essential.
  • Experience in nucleic acid amplification and/or Reproductive Health (NIPT, Carrier Screening, Pre-eclampsia, Endometriosis, etc) is required.
  • Skilled at writing clear plans, protocols, reports and manuscripts.
  • Excellent cross-functional team participation skills - thrives in a dynamic, fast-paced organization and matrixed environment.
  • Solid track record of building strong relationships and working with different personality types and all levels inside and outside the company.
  • Displays natural integrity, humility and authenticity.
  • Is committed to Diversity and Inclusion.

About Bio-Rad:

Bio-Rad is a global leader providing a broad array of clinical diagnostics and life science research products. With a team of more than 8,000 employees and a global network of operations serving our customers, we help people live longer, healthier lives.

Bio-Rad was founded over six decades ago and has continued to provide the healthcare industry with innovative and useful products that help life science researchers accelerate the discovery process and medical diagnostic labs obtain faster, better results.

EEO/AA Employer/Veterans/Disabled/Race/Ethnicity/Gender/Age

Agency Non-Solicitation:

Bio-Rad does not accept agency resumes, unless the agency has been authorized by a Bio-Rad Recruiting Representative. Please do not submit resumes unless authorized to do so. Bio-Rad will not pay for any fees related to unsolicited resumes.


Keywords: Bio-Rad Laboratories, Pleasanton , Staff Scientist, Applications Development (Molecular Diagnostics), Other , Pleasanton, California

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