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Staff Scientist-Process Development & Validation (P-374)

Company: 10x Genomics
Location: Pleasanton
Posted on: January 10, 2022

Job Description:

At 10x Genomics, accelerating our understanding of biology is more than a mission for us. It is a commitment. This is the century of biology, and the breakthroughs we make now have the potential to change the world.

We enable scientists to advance their research, allowing them to address scientific questions they did not even know they could ask. Our tools have enabled fundamental discoveries across biology including cancer, immunology, and neuroscience.

Our teams are empowered and encouraged to follow their passions, pursue new ideas, and perform at their best in an inclusive and dynamic environment. We know that behind every scientific breakthrough, there is a deep infrastructure of talented people driving the life sciences industry and making it possible for scientists and clinicians to make new strides. We are dedicated to finding the very best person for every aspect of our work because the innovations and discoveries that we enable together will lead to better technologies, better treatments, and a better future. Find out how you can make a 10x difference.

About The Role

We are seeking an outstanding Staff Scientist to join the Process Development team and lead a team in the development and validation of downstream production processes for 10x reagents and consumables. The Process Development team interfaces between early stage R&D and Production is deeply embedded in both organizations. This position works cross-functionally with multiple groups such as Chemistry, Microfluidics, Molecular Biology, Engineering, QC, Production, and Supply Chain.

Candidates must have a broad working knowledge of chemical engineering and NGS reagents, and be able to independently and creatively translate those principles to develop and implement infrastructure at commercial scale in a full Production facility. This is a lead from the bench role with initially more than 50% of time spent at the bench. The successful applicant will have exceptional attention to detail and the ability to meticulously execute and analyze highly complex experiments. Previous industry experience successfully commercializing and supporting similar processes is essential.

Individuals applying for this position must be self-starters, strategic thinkers, action driven, flexible in changing direction and methods, thrive in a fast paced environment, excel at managing multiple priorities, succeed in communicating with all levels within the organization and provide immediate contribution.

What You Will Be Doing

  • On time delivery of robust production processes to support manufacturing of 10x reagents and consumables
  • Drive infrastructure development projects for delivery of NGS reagents into both commercial and custom consumable configurations.
  • Develop, characterize and optimize a broad range of processes to deliver reagents into appropriate consumable configurations and ensure filling, finishing, and labeling activities are in control and meet downstream requirements.
  • Design, develop, validate, and implement appropriate QC methods to ensure processes are in control.
  • Lead a team of scientists dedicated to the development and validation of downstream production processes for 10x reagents and consumables.
  • Hire exceptional people to build a high performing team.
  • Design and conduct experiments to determine underlying reaction mechanisms, cause and effect, failure modes, guard band studies and optimization using DOE methodologies.
  • Independently troubleshoot and resolve issues with incoming material, production and QC processes.
    To Be Successful, You Will Need
    • PhD (or equivalent experience) in chemical engineering
    • 8+ years relevant biotechnology or pharmaceutical industry experience (Staff Scientist)
    • Demonstrated record of successful technology transfer from early R&D concepts into customer-facing products.
    • Strong Process Transfer experience demonstrating control of manufacturing processes through appropriate Process Design and QC methods.
    • Solid understanding of a wide variety of NGS reagents.
    • Experience operating liquid handling robots and other laboratory automation tools.
    • Experience designing post processing workflows to ensure reagents meet stability and shipping requirements.
    • Ability to integrate a broad range of scientific and engineering disciplines.
    • Ability to design meaningful experiments and perform in-depth analysis of results.
    • Strong collaboration and communication skills.
    • Desire to work in a flexible and fast-paced startup environment
      Nice To Have
      • Experience using statistical tools, such as JMP to analyze complex data sets.
      • Previous work with custom reagent vendors and setting up OEM relationships.
        Individuals seeking employment at 10x Genomics are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.

        10x does not accept unsolicited applicants submitted by third-party recruiters or agencies. Any resume or application submitted to 10x without a vendor agreement in place will be considered unsolicited and property of 10x, and 10x will not pay a placement fee.

Keywords: 10x Genomics, Pleasanton , Staff Scientist-Process Development & Validation (P-374), Other , Pleasanton, California

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