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Senior Scientist

Company: Genentech
Location: Pleasanton
Posted on: January 20, 2023

Job Description:

The PositionThe Pathology Biology & Integrated Analytics group (Pleasanton, CA) at Roche Diagnostics is seeking a highly motivated Senior Scientist with extensive experience in immunohistochemistry (IHC) assay to support antibody development and antibody production process development. The qualified candidate will join a team of scientists focused on monoclonal antibody development for IVD and CDx assay. This position will be actively participating in the de novo development of rabbit monoclonal antibodies for immunohistochemistry and also participating in the development and optimization of hybridoma cell culture and other mammalian cell culture processes as well as downstream purification processes for monoclonal antibody production.This position will be expected to coordinate with Operation team for method transfer and assist in troubleshooting manufacturing issues to determine root causes and possible engineering solutions. Job function requires the ability to evaluate, summarize and report study results, make independent decision and collaborate with other functional groups including Quality and Operation.Responsibilities

  • Provide technical leadership to the team with an emphasis on Immunohistochemistry, using a strong knowledge base for guiding development/optimization/validation design, problem solving, and presenting proposals and results for projects within the company and externally.
  • Conduct immunohistochemistry experiments to facilitate antibody screening and optimize IHC testing condition of final product on different platforms.
  • Provide support in slide reviewing, clone selection and organizing downstream working process results to guide the antibody clone development process, to support QC testing of production lots for process development, and to provide on-market support and troubleshooting efforts.
  • Prepare immunohistochemistry solutions and reagents and routine maintenance and cleaning of equipment and troubleshoot minor equipment failures. Process paperwork associated with tissue archiving, IHC testing, reagent preparation.
  • Develop and optimize staining protocols for singleplex and multiplexed assays examining molecular targets in intact human tissues.
  • Capable to apply other tissue based technologies such as RNAish.
  • Actively collaborates and shares knowledge with other members of the team.
  • Prepare and delivers presentations of project results to others; presents data to larger and more diverse audiences.
  • Apply advanced technical writing skills to produce reports and documents; writes independently; evaluates the writing of others.
  • Provide leadership on project design and feasibility studies.Qualifications
    • Bachelors degree plus 10 years relevant experience OR Masters Degree plus 5 years OR PhD and 2 years relevant experience.
    • Three (3) or more years of experience with immunohistochemistry (IHC) based methods.
    • Background in Pathology/Histology/Oncology and antibody development experience is preferred.Knowledge, Skills and Abilities
      • Deep understanding of the technical and scientific underpinnings of IHC based methods and assay optimization techniques.
      • Experiences working with IHC autostainers, such as BenchMark Ultra, is a plus.
      • Experience and knowledge in rabbit monoclonal antibody development preferred.
      • Demonstrated record of scientific accomplishment, with a history of publications and presentations.
      • Strong work ethic and collaborative attitude.
      • Possesses excellent communication and interpersonal skills, enthusiasm to work collaboratively with others, and a strong drive to solve problems, overcome obstacles, and innovate.
      • High level of comfort with complex multitasking; be self-motivated and productive; and be able to work independently, with minimal oversight.The expected salary range for this position based on the primary location of Pleasanton, CA is $130,000 to $150,000. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below. Relocation benefits are not offered for this role.Genentech is an equal opportunity employer, and we embrace the increasingly diverse world around us. Genentech prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity or expression, national origin or ancestry, age, disability, marital status and veteran status.Genentech requires all new hires to be fully vaccinated against COVID-19 as of their start date. This requirement is a condition of employment at Genentech, and it applies regardless of whether the position is located at a Genentech campus or is fully remote. If you are unable to receive the vaccine due to a disability or serious medical condition, or because it is prohibited as a result of your sincerely held religious beliefs, you will have an opportunity to request a reasonable accommodation.

Keywords: Genentech, Pleasanton , Senior Scientist, Other , Pleasanton, California

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